Damaros^™

The agentic execution platform for clinical trials.

Start a pilot

A demonstration of the Damaros^™ runtime on synthetic FHIR data. Click on the pulsing box to walk through it.

Live · synthetic FHIR

Protocol Ingested · locked v2.1 LLM fetched NCT03032484 · parsed sponsor packet · 06-21 14:02Z

DMR-204 · EGFR-mutant NSCLC

NCT03032484 · Phase II · randomized 1:1 · hash aead45cf

Amendment cascade

v2.0 · 04-12 v2.1 · 06-21

Narrowed prior-lines criterion · re-screen triggered

Sponsor

Meridian Oncology Therapeutics

NCT03032484 DMR-204 · v2.1 Phase II

Dr. E. Salgado

Medical Monitor

J. Okafor

Lead CRA

trials@meridian-onc.com

Study arms · LLM-parsed from packet

ARM A

Velartinib · 80 mg PO daily

Investigational · oral 3rd-gen EGFR-TKI

ARM B

Platinum doublet

Comparator · standard of care

Randomized 1:1 · target n=140 · stratified by ECOG & prior lines

Eligibility · 36 criteria · 25 Trident-mapped

Evidence how Trident maps the sponsor packet onto site evidence · PHI-bounded · 09:43

Sponsor packet → evidence coverageTrident mapped 25 of 36 criteria · Protocol v2.1

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Protocol obligations · source mapping

Maps to {{ ev.detail.requiredBy }} · {{ ev.detail.arm }}

Current{{ ev.detail.current }}

Source plane{{ ev.detail.sourcesText }}

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ProvenanceNo model verdict · source trace available

Coordinator step-in

No judgment required

Computable from source. Maps deterministically once the evidence lands.

Routed · {{ ev.detail.actedTicket }}

Screening Protocol v2.1

Patient queue · decisive criterion

Primary blocker

Normalized rule

Patient facts used

Evidence sources

Deterministic result

Review trigger

Recommended next action

Resolve {{ awaiting }} awaiting judgment · {{ committedCount }} committed

≠

Decision signed · bound to Replay

ReviewerYou

Role{{ cur.role }}

Protocolv2.1 · aead45cf

PHIexcluded

Your call

Replay

Subject S-1047 · DMR-204 · Site 018 · Protocol v2.1 · Run {{ rp.runId }} · 06-22

Reconstruction ledger

TimeEventActorIntegrity

Selected event

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Related events

Works with your existing systems

Not a replacement. The platform unifies the stack you already run.

The problem

Care is everywhere.
Clinical trials aren't.

CTMS tracks it. EDC captures it. eTMF files it. But execution is still missing: turning a protocol into a patient who can actually be screened.

The work still lives in the gap: charts, labs, notes, criteria, coordinator judgment, PI review, and proof rebuilt later. Every protocol and disconnected system adds weight. Large centers absorb more. Community clinics often cannot.

~80%

of cancer patients are treated in community clinics, not academic centers.

Community Oncology Alliance

enroll in a trial at community programs, versus ~22% at NCI-designated cancer centers.

JNCI Cancer Spectrum

20+

disconnected systems the average site runs daily, with nothing unifying them.

SCRS · WCG

~30%

annual turnover among research coordinators as workload outpaces capacity.

ACRP Workforce

The workflow

One run. Protocol to proof.

Engine accelerates. Humans decide. Replay proves.

01Protocol

Intent becomes logic.

An LLM lifts criteria from the sponsor packet and NCT registry; Trident compiles them into locked, versioned logic, byte-identical at every site.

02Evidence

Records become evidence.

Site-approved data arrives screening-ready, lineage, freshness, mapping. PHI never meets a model.

03Screening

A verdict, not a guess.

A deterministic engine runs every criterion. Anything unclear routes to a human.

PASS REVIEW FAIL

04Resolve

Judgment, then signature.

Luna-governed agents stage the decision. A person commits it, bound to Replay.

05Replay

Execution becomes proof.

Reconstruct any run end to end. Hash-verified, signed, PHI-free.

The outputs

Not a dashboard. A decision you can defend.

Every run carries a complete manifest: every state, the cited evidence behind it, the human who made the call, and a signed replay bundle that reconstructs the whole decision.

Input

Protocol v2.1 · locked

NCT03032484 · hash aead45cf

Site-approved cohort · 72 patients

Synthetic · site-governed

Evidence snapshot · 1,284 resources

FHIR R4 · pop-2026-06-22

deterministic engine→

Output · execution record

Subject 018-017

DMR-204 · v2.1 · I-3.4

Serum chemistry within 7-day window

DriverStale · evidence past the freshness window

EvidenceObservation · K⁺ 5.0 mmol/L · drawn 06-09
Epic / FHIR R4 · retrieved 06-20

ActionCoordinator requested repeat panel

ResolveSub-I deferred eligibility pending updated K⁺

ReplayPartially replayable until updated evidence arrives

Reviewer A. Reyes · PI / Sub-I · bound to Replay · PHI-free

The runtime

Damaros^™ runs the site.

It admits site-approved evidence, screens against locked logic, routes uncertainty to the right human, and seals every decision into Replay.

What it controls

Site-approved evidence sources

Review adjudication & clinician confirmation

Local evidence visibility & artifact release

Network-safe signal emission

What it does not

Become a network-controlled endpoint

Expose raw chart browsing by default

Replace clinician judgment

Send PHI out of the site or let an LLM touch patient data

Replay · proof

Not a log you trust. Proof you can replay.

Reconstruct any run end to end with Damaros™

Replay manifest RPL-2026-0622-018-1047

01Protocollocked v2.1

02Evidencesnapshot

03Screeningdeterministic

04Resolvehuman-signed

Replaysealed

Protocol basis

v2.1 · aead45cf

Evidence snapshot

pop-2026-06-22

Signature

Ed25519 · verified

GET STARTED

Run one protocol through Damaros^™

What you get

Protocol execution map

Every criterion compiled into locked, versioned logic a system can run.

Evidence coverage report

Exactly what's ready, stale, missing, or unmapped, criterion by criterion.

Review burden & drivers

Precisely where human judgment is required, and what drives it.

Replay completeness package

A signed, PHI-free record that reconstructs every decision.

Site-readiness signal

A network-safe, de-identified view of who is ready to run.

Output comparable to a full execution-readiness assessment. Start a pilot

Security posture

Every run is attributable.
PHI never reaches a model.

PHI never reaches a model · bounded at the site

SOC 2-aligned controls & audit logging

FedRAMP-oriented architecture

Replayable proof · signed & hash-verified

HIPAA-informed architecture BAA / DPA · HIPAA-aligned

Air-gapped or institution-hosted

Encryption in transit & at rest · key rotation

RBAC · tenant isolation · OIDC / SAML

We validate the execution chain. We do not claim clinical efficacy.

Trial delays are treatment delays.